a microwave-assisted bismuth nitrate-catalyzed unique route toward 1,4-dihydropyridines对1微波铋nitrate-catalyzed独特的路线,4-dihydropyridines.pdfVIP

Molecules 2012, 17, 2643-2662; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 1,4-Dihydropyridines Debasish Bandyopadhyay, Stephanie Maldonado † and Bimal K. Banik * Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX 78539, USA † Undergraduate research participant. * Author to whom correspondence should be addressed; E-Mail: banik@; Tel.: +1-956-665-8741; Fax: +1-956-384-5006. Received: 6 February 2012; in revised form: 26 February 2012 / Accepted: 27 February 2012 / Published: 5 March 2012 Abstract: The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/ammonium acetate, aldehydes and 1,3-dicarbonyl compounds within 1–3 min under solvent-free conditions. The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules. The excellent yield and extreme rap