a novel antioxidant isobenzofuranone derivative from fungus cephalosporium sp.al031一种新型抗氧化剂isobenzofuranone导数从真菌cephalosporium sp.al031.pdfVIP

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a novel antioxidant isobenzofuranone derivative from fungus cephalosporium sp.al031一种新型抗氧化剂isobenzofuranone导数从真菌cephalosporium sp.al031.pdf

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a novel antioxidant isobenzofuranone derivative from fungus cephalosporium sp.al031一种新型抗氧化剂isobenzofuranone导数从真菌cephalosporium sp.al031

Molecules 2012, 17, 4219-4224; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031 1 1 1 1 1 Xiang-Zhong Huang , Yun Zhu , Xiao-Li Guan , Kai Tian , Jun-Ming Guo , Hong-Bin Wang 1 and Guang-Miao Fu 2,* 1 Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China 2 School of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China * Author to whom correspondence should be addressed; E-Mail: fugmiao@; Tel./Fax: +86-371-6568-0011. Received: 5 March 2012; in revised form: 20 March 2012 / Accepted: 26 March 2012 / Published: 5 April 2012 Abstract: Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl- 1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7- methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 1–4 showed