a scoring matrix approach to detecting mirna target sites得分矩阵方法检测microrna的目标网站.pdfVIP

Algorithms for Molecular Biology BioMed Central Research Open Access A scoring matrix approach to detecting miRNA target sites Simon Moxon, Vincent Moulton and Jan T Kim* Address: School of Computing Sciences, University of East Anglia, Norwich, NR4 7TJ, UK Email: Simon Moxon - simonm@cmp.uea.ac.uk; Vincent Moulton - vincent.moulton@cmp.uea.ac.uk; Jan T Kim* - jtk@cmp.uea.ac.uk * Corresponding author Published: 31 March 2008 Received: 5 October 2007 Accepted: 31 March 2008 Algorithms for Molecular Biology 2008, 3:3 doi:10.1186/1748-7188-3-3 This article is available from: /content/3/1/3 © 2008 Moxon et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Experimental identification of microRNA (miRNA) targets is a difficult and time consuming process. As a consequence several computational prediction methods have been devised in order to predict targets for follow up experimental validation. Current computational target prediction methods use only the miRNA sequence as input. With an increasing number of experimentally validated targets becoming available, utilising this additional information in the search for further targets may help to improve the specificity of computational methods for target site prediction. Results: We introduce a generic target prediction method,