a preliminary pharmacokinetic study of betulin, the main pentacyclic triterpene from extract of outer bark of birch (betulae alba cortex)初步的药代动力学研究桦木醇,主要提取的五环三萜烯的外层树皮桦木(betulae alba皮层).pdfVIP

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a preliminary pharmacokinetic study of betulin, the main pentacyclic triterpene from extract of outer bark of birch (betulae alba cortex)初步的药代动力学研究桦木醇,主要提取的五环三萜烯的外层树皮桦木(betulae alba皮层).pdf

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a preliminary pharmacokinetic study of betulin, the main pentacyclic triterpene from extract of outer bark of birch (betulae alba cortex)初步的药代动力学研究桦木醇,主要提取的五环三萜烯的外层树皮桦木(betulae alba皮层)

Molecules 2008, 13, 3224-3235; DOI: 10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A Preliminary Pharmacokinetic Study of Betulin, the Main Pentacyclic Triterpene from Extract of Outer Bark of Birch (Betulae alba cortex) Sebastian Jäger 1,*, Melanie N. Laszczyk 1,2 and Armin Scheffler 1 1 Carl Gustav Carus-Institut, Am Eichhof 30, D-75223 Niefern-Öschlbronn, Germany; E-mail: info@carus-institut.de (A. S.) 2 Betulin-Institut, Blumenstrasse 24, D-64297 Darmstadt, Germany; E-mail: m.laszczyk@betulin- institut.de (M-N. L.) * Author to whom correspondence should be addressed; E-mail: sebastian.jaeger@carus-institut.de； Tel.: +49 7233 68 422; Fax: +49 7233 68 403. Received: 31 October 2008; in revised form: 10 December 2008 / Accepted: 17 December 2008/ Published: 18 December 2008 Abstract: During the last two decades triterpenes have attracted attention because of their pharmacological potential. Triterpene extract (TE) from outer bark of birch consisting mainly of betulin is able to form an oleogel which was successfully tested in the treatment of actinic keratosis. Some aspects of TE in vitro pharmacology are already known. Now we show preliminary pharmacokinetics of betulin and results of a subchronic toxicity study of TE in rats and dogs. Because of poor aqueous solubility of the TE-triterpenes ( 0.1 µg/mL respectively), for pharmacokinetic studies it was suspended in sesame oil (rats, i.p.) and PEG 400 / 0.9 % NaCl (dogs, s.c.). I.p.