a new model for rheumatoid arthritis类风湿性关节炎的新模型.pdfVIP

/content/2/2/085 Commentary A new model for rheumatoid arthritis? Hugh McDevitt Stanford University School of Medicine, Stanford, California, USA Received: 14 December 1999 Arthritis Res 2000, 2:85–89 Revisions requested: 10 January 2000 The electronic version of this article can be found online at Revisions received: 19 January 2000 /content/2/2/085 Accepted: 19 January 1999 Published: 9 February 2000 © Current Science Ltd Abstract A chance observation has led to the development of a new murine model for inflammatory arthritis. Arthritis is induced, and transferred, by T-cell-dependent antibodies to glucose-6- phosphate isomerase. This enzyme is expressed in all cells, and is detectable in serum. There are several similarities to rheumatoid arthritis (RA) in the murine disease. This elegant model raises several questions as to how and why a systemic response focuses inflammation so strongly on synovial joints. The model also re-introduces the possibility that antibodies to widely expressed self-proteins may play a role in the pathogenesis of RA. Keywords: animal models, antibody transfer, rheumatoid arthritis, system antigens Introduction showed that patients with chronic, active, rheumatoid The etiology and pathogenesis of rheumatoid arthritis (RA) factor-positive RA had a striking increas