原创力文档a microsatellite-based analysis for the detection of selection on bta1 and bta20 in northern eurasian cattle (bos taurus) populationsmicrosatellite-based分析检测的选择bta1和欧亚大陆北部bta20牲畜(牛)的人口.pdfVIP
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a microsatellite-based analysis for the detection of selection on bta1 and bta20 in northern eurasian cattle (bos taurus) populationsmicrosatellite-based分析检测的选择bta1和欧亚大陆北部bta20牲畜(牛)的人口
Li et al. Genetics Selection Evolution 2010, 42:32 Ge n e t i c s
/content/42/1/32
Se l e c t i o n
Evolution
RESEARCH Open Access
A microsatellite-based analysis for the detection
of selection on BTA1 and BTA20 in northern
Eurasian cattle (Bos taurus) populations
*
Meng-Hua Li, Terhi Iso-Touru, Hannele Laurén, Juha Kantanen
Abstract
Background: Microsatellites surrounding functionally important candidate genes or quantitative trait loci have
received attention as proxy measures of polymorphism level at the candidate loci themselves. In cattle, selection
for economically important traits is a long-term strategy and it has been reported that microsatellites are linked to
these important loci.
Methods: We have investigated the variation of seven microsatellites on BTA1 (Bos taurus autosome 1) and 16 on
BTA20, using bovine populations of typical production types and horn status in northern Eurasia. Genetic variability
of these loci and linkage disequilibrium among these loci were compared with those of 28 microsatellites on other
bovine chromosomes. Four different tests were applied to detect molecular signatures of selection.
Results: No marked difference in locus variability was found between microsatellites on BTA1, BTA20 and the other
chromosomes in terms of different diversity indices. Average D′ values of pairwise syntenic markers (0.32 and 0.28
across BTA 1 and BTA20 respectively) were significantly (P 0.05
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