a new o-terpenoidal coumarin from clausena anisum-olens merr.一个新的o-terpenoidal香豆素从黄anisum-olens稳定。.pdfVIP

Molecules 2009, 14, 771-776; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A New O-Terpenoidal Coumarin from Clausena anisum-olens Merr. Yun-Song Wang 1, Hong-Yi Xu 2, Da-Xiang Wang 1 and Jing-Hua Yang 1,* 1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R. China; E-mails: wangys@ (Y.-S.W.); yangjh@ (J-H.Y.) 2 Department of Public Security of Yunnan Province, Kunming 650031, P. R. China; E-mails: hongyix@ (H-Y. X.) * Author to whom correspondence may be addressed; E-mail: yangjh@; Tel: +86-871-6598387; Fax: +86-871-5035538. Received: 5 December 2008; in revised form: 6 February 2009 / Accepted: 9 February 2009 / Published: 13 February 2009 Abstract: A new O-terpenoidal coumarin 1, named hekumarone, was isolated from the leaves and twigs of Clausena anisum-olens Merr. (Rutaceae) collected in Hekou County in Yunnan Province, P. R. China. Structure elucidation and unambiguous NMR assignments for the title compound was carried out on the basis of 1D and 2D NMR experiments. Keywords: Rutaceae; Clausena anisum-olens Merr.; Hekumarone; Monoterpenoid coumarins. Introduction The plants of the Rutaceae family are well-known to contain structurally diverse and biologically active coumarins [1-6]. Within this family, the plants of the genus Clausena are shrubs, widely distributed in South and Southeast Asia and many species