a new natural ceramide from trollius chinensis bunge一个新的自然从金莲花bunge神经酰胺.pdfVIP

Molecules 2010, 15, 7467-7471; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A New Natural Ceramide from Trollius chinensis Bunge Ru-Feng Wang 1, Rui-Ning Liu 2, Tong Zhang 3,* and Tao Wu 3 1 School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China; E-Mail: wangrufeng@ (R-F.W.) 2 Department of Pharmacy, First Hospital of Tsinghua University, Beijing 100016, China; E-Mail: lrnthu@ (R-N.L.) 3 Experiment Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China * Author to whom correspondence should be addressed; E-Mail: zhangtdmj@. Received: 16 August 2010; in revised form: 20 September 2010 / Accepted: 18 October 2010 / Published: 25 October 2010 Abstract: A new natural product named trolliamide was isolated from Trollius chinensis Bunge. Its structure was determined as 2-hydroxy-tetracosanoic acid(2,3-dihydroxy-1- hydroxymethyl-heptadec-7-enyl)-amide by spectroscopic methods, including UV, IR, MS and NMR. This is the first report of a ceramide isolated from Trollius chinensis. Keywords: Trollius chinensis; constituents; ceramide Introduction Trollius chinensis Bunge (Ranunculaceae) is a perennial herb widely distributed in northern China [1]. Its flowers, known as Jinlianhua in China, have been used by Chinese people for a long time to treat respiratory infections, pharyngitis, tonsillitis, and bronchitis [2]. Phytochemical studies reported that these flowers mainly contain fla