西松烷型二萜对小鼠h22肝癌腹水瘤的抑制作用及其机制（The inhibitory effect and its mechanism of two terpene terpenes on H22 hepatoma ascites in mice）.docVIP

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西松烷型二萜对小鼠h22肝癌腹水瘤的抑制作用及其机制（The inhibitory effect and its mechanism of two terpene terpenes on H22 hepatoma ascites in mice）.doc

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西松烷型二萜对小鼠h22肝癌腹水瘤的抑制作用及其机制（The inhibitory effect and its mechanism of two terpene terpenes on H22 hepatoma ascites in mice）

西松烷型二萜对小鼠h22肝癌腹水瘤的抑制作用及其机制（The inhibitory effect and its mechanism of two terpene terpenes on H22 hepatoma ascites in mice） The inhibitory effect and its mechanism of two terpene terpenes on H22 hepatoma ascites in mice This article source: paper / Author: Chen Hong Lv Hongying Cui Yan Zi Huapu Fuxian Guo Yunliang Wang Xiumei [Abstract] Objective To study the inhibitory effect of two type of terpenoid of Mongolian pine on H22 ascites tumor in mice and explore its mechanism. Methods Kunming mice H22 ascites tumor model, were randomly divided into saline group (I group), cembrane type two from the low dose group (Group II), middle dose group (Group III), high dose group (IV group) and cyclophosphamide group (Group V). After modeling 24 h administered, II ~ IV group with different doses of cembrane type diterpenes two continuous intragastric administration of 7 d, the control group was given the same volume of normal saline, group V intraperitoneally injected cyclophosphamide 7 d, 24 h after the last administration were half animal. The average ascites volume, ascites suppression rate, tumor cell number, tumor cell survival rate, cytokine interleukin 2 (IL 2) and interferon gamma (IFN gamma) concentration were calculated. The other half continued to observe survival, calculate survival and prolong survival. The results of group III, IV and I compared the amount of ascites was significantly reduced (f=28.37, q=2.91, 4.76, p 0.05), ascites inhibition rate increased with dose. II ~ IV group tumor cell count and tumor cell survival rate decreased significantly compared with group I (f=7.21-19.13, q=2.92 ~ 4.76, p 0.05). II ~ IV group were compared with the average survival period was significantly prolonged (f=35.77 1, q=2.91 ~ 4.75, p 0.05), extension rates were 20.21%, 42.10% and 51.02%. Compared with group V, II, III group of mice in the diet, activities and other aspects of good state. Decreased appetite during IV group activities, improved after drug withdrawal. II ~