antibiotics in critically ill patients a systematic review of the pharmacokinetics of β-lactams抗生素在危重患者的药物动力学系统回顾β-lactams.pdfVIP

Gonçalves-Pereira and Póvoa Critical Care 2011, 15:R206 /content/15/5/R206 RESEARCH Open Access Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of b-lactams Joao Gonçalves-Pereira1,2* and Pedro Póvoa1,2 Abstract Introduction: Several reports have shown marked heterogeneity of antibiotic pharmacokinetics (PK) in patients admitted to ICUs, which might potentially affect outcomes. Therefore, the pharmacodynamic (PD) parameter of the