双氯芬酸钠肠溶片（Diclofenac Sodium Enteric-coated Tablets）.docVIP

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双氯芬酸钠肠溶片（Diclofenac Sodium Enteric-coated Tablets）.doc

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双氯芬酸钠肠溶片（Diclofenac Sodium Enteric-coated Tablets）

双氯芬酸钠肠溶片（Diclofenac Sodium Enteric-coated Tablets） Diclofenac Sodium Enteric-coated Tablets Name used before English name DICLOFENAC, SODIUM, ENTERIC-COATED, TABLETS Pinyin name SHUANGLUFENSUANNA CHANGRONGPIAN Antipyretic, analgesic and non steroidal anti-inflammatory and analgesic drugs Properties of this product are enteric coated tablets, which show white after removing enteric coating. Pharmacology and toxicology of this product through inhibition of cyclooxygenase and reduce prostaglandin synthesis, and the formation of a certain extent inhibit lipoxygenase and reduce products such as leukotrienes, bradykinin exert analgesic and anti-inflammatory and antipyretic effect. It has been proved to be antipyretic in animal experiments and in human clinical practice. Acute toxicity test: the rats were orally LD50 with 150mg/kg, and the oral LD50 was 390mg/kg. Pharmacokinetics, oral absorption, rapid, complete. Reduce the rate of absorption with food. Serum concentrations of fasting drugs reached an average of 1~2 hours, peaking at 6 hours with food and decreasing plasma levels. The half-life of the drug is about 2 hours. The binding rate of plasma protein was 99%. In the milk, the concentration of Chinese medicine is very low and can be neglected. In the synovial fluid, the medicine is taken for 4 hours, and the level is higher than the serum level at that time, and it can last 12 hours. About 50% metabolism in the liver, 40% to 65% from the kidneys, 35% from the bile, feces excreted 1.2 ~ 2 hours after the end of excretion. Prolonged use without accumulation. Indications: for ease arthritis rheumatoid arthritis, osteoarthritis, spinal arthritis, gouty arthritis, rheumatoid arthritis and other symptoms of joint pain; pain of soft tissue in the treatment of non rheumatic joints, such as shoulder pain, tenosynovitis, bursitis, myalgia and pain after exercise injury; acute mild and moderate pain after surgery, trauma, strain, dysmenorrhea, toothache, headache and so on; i