喜炎平注射液对手足口病患儿血清细胞因子水平影响.docVIP

喜炎平注射液对手足口病患儿血清细胞因子水平影响[摘要] 目的 研究喜炎平注射液治疗手足口病患儿的疗效及对患者血清IL-2、IL-6、IL-10及TNF-α等细胞因子水平的影响。 方法 60例手足口病患儿依治疗方法不同分为观察组和对照组。对照组采用利巴韦林治疗。观察组在对照组方法的基础上加用喜炎平注射液治疗。 结果 观察组显效率76.67%高于对照组显效率50.00%，差异有统计学意义（P 0.05）。 结论 喜炎平注射液用于治疗手足口病患儿疗效确切、副作用少，而且可以明显改善患者的血清IL-2、IL-6、IL-10及TNF-α等细胞因子水平。 [关键词] 喜炎平注射液；利巴韦林；手足口病；IL-2；IL-6；IL-10；TNF-α [中图分类号] R725.1 [文献标识码] B [文章编号] 1673-9701（2013）07-0081-02 Study of Xiyanping injection intervention on serum cytokine levels in children with hand foot and mouth disease WU Ye1 SHEN Jianqiang2 1.Department of Pediatrics， Huzhou Central Hospital in Zhejiang Province. Huzhou 313000， China； 2.Department of Urology，Huzhou Central Hospital in Zhejiang Province. Huzhou 313000，China [Abstract] Objective To study the effect of Xiyanping injection in the treatment of children with hand foot and mouth disease and interventions serum IL-2， IL-6， IL-10 and TNF-α levels in patients. Methods In 60 cases of children with hand foot and mouth disease，were randomLy divided into the observation group and control group. Control group：the use of ribavirin in treatment of hand foot mouth disease. The observation group： in the control group method based on， plus Xiyanping injection in the treatment of hand foot mouth disease. Results Significant efficiency of the observation group was 76.67% higher than 50.00% in the control group，the difference was statistically significant（P 0.05）. Conclusion Xiyanping injection used in the treatment of children with hand foot and mouth disease has good curative effect， less side effects ，and can improve the levels of serum IL-2， IL-6， IL-10 and TNF-α. [Key words] Xiyanping Injection； Ribavirin； Hand foot and mouth disease； IL-2； IL-6； IL-10； TNF- α 手足口病是由多种肠道病毒（各型柯萨奇、埃可病毒和EV71）引起的儿科常见传染病[1]，临床以口腔黏膜、手、足、臂、膝等部位皮肤出现皮疹为主要表现，而且易并发心肌损害。文献表明[2]，中药制剂喜炎平注射液具有抗病毒、抗菌、解热消炎、镇咳、增强机体免疫等功能。而且在常规抗病毒西药治疗基础上联合喜炎平注射液治疗手足口病患儿具有较好的疗效[3]。本研究评价了喜炎平注射液治疗手足口病患儿的疗效，并观察了其对患者血清IL-2、IL-6、IL-10及TNF-α等细胞因子水平的影响，现报道如下。 1 资料与方法 1.1 病例选择