glutathione treatment on anti-tb drug-induced efficacy of drug-induced hepatitis（谷胱甘肽治疗抗结核药物引起药物引起肝炎的效果）.docVIP

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glutathione treatment on anti-tb drug-induced efficacy of drug-induced hepatitis（谷胱甘肽治疗抗结核药物引起药物引起肝炎的效果）.doc

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glutathione treatment on anti-tb drug-induced efficacy of drug-induced hepatitis（谷胱甘肽治疗抗结核药物引起药物引起肝炎的效果）

Glutathione treatment on anti-TB drug-induced efficacy of drug-induced hepatitis [Abstract] Objective To study the treatment of anti-TB drugs reduced glutathione due to drug-induced hepatitis. Methods 48 cases of clinical drug-induced liver damage by the patients were divided into treatment group and control group 24 cases, the treatment group using Google glutathione injection. were measured before and after treatment ALT, total bilirubin (STB, and observation of clinical symptoms to evaluate the efficacy results of glutathione after treatment, the patient ALT, STB than the control group decreased significantly (P lt;0.05, The total effective rate was 79.2%. Conclusion glutathione can significantly improve anti-TB drug-induced drug-induced hepatitis ALT, STB and other indicators. [Keywords] tuberculosis drug-induced hepatitis and liver damage liver function 1 General Materials and Methods 1.1 Clinical data 48 patients, all hospital inpatients, the use of anti-TB drug treatment, there are different levels of drug-induced liver damage, namely fatigue, abdominal distension, dark urine, liver damage, and exclusion of viral hepatitis and other causes of elevated ALT. 1.2 Treatment 48 patients were randomly divided into two groups, the treatment group of 24 patients in the control group of 24 patients in control group of daily intravenous tiopronin, glutathione 1.8g treated with intravenous infusion, 1 / d, and observe patients with symptoms such as nausea, vomiting, abdominal distension, urine, etc., a weekly review of urine routine, liver function, etc., half of a course of treatment. 1.3 determine the efficacy of Effective: Clinical symptoms and signs disappeared, normal liver function. Effective: disappearance of clinical symptoms and physical symptoms, liver function returned to 50% invalid: not reached the target. 1.4 statistical processing Count data by x2 test, with P lt;0.05 was considered statistically significant.