1328例颈动脉狭窄支架成形术患者脑保护技术的临床应用.docVIP

1328例颈动脉狭窄支架成形术患者脑保护技术的临床应用 李华康1 迟路湘1 赵刚2 刘之荣2 向立全3 李鱼3 田杰3 杜彦辉4 马斌武4 陈桂生4（1 400038重庆第三军医大学西南医院心血管内科，重庆市介入心脏病学研究所摘要目的 观察脑保护下颈动脉狭窄术的临床疗效和安全性。方法 2003年4月至2010年6月术治疗颈动脉狭窄患者。结果 1328例患者均顺利将脑保护装置于颈动脉入颅处患者治疗前颈动脉的平均狭窄率为（88.2±6.7）%，治疗后为（19.2±11.1）%，治疗后颈动脉狭窄明显（P0.01）。其中768例患者进行了平均1年随访，无死亡、缺血性脑卒中发生。结论是治疗颈动脉狭窄预防缺血性脑卒中的安全和有效方法。颈动脉狭窄；脑保护装置；支架；成形术linical application of 1328 patients of carotid ?angioplasty with stenting using?cerebral?protection technology? LI Huakang，LuXiang （Department of Cardiology?of?Southwest?Hospital?of?Third Military Medical University， Chongqing?City，?Interventional Cardiology?Research Institute，?Chongqing 400038Abstract] Objective:To observe?the?clinical?efficacy and safety of using cerebral protection devices?and stent angioplasty in the treatment of patients with carotid artery stenosis. Method:The clinical data of 1328 patients with carotid stenosis treated with cerebral protection devices?and stent angioplasty from April 2003 to June 2010 were analyzed retrospectively．The safety and efficacy of the operation was analyzed.Results:1328 cases?were?smooth?cerebral protection device?in?the?carotid?artery?into?the?skull? Patients．efore treatment，the?average?carotid artery?stenosis rate （88.2?±?6.7）%? after treatment?（19.2 ±?11.1）%， after treatment?of carotid stenosis?was significantly?reduced?（P?0.01）The 768 patients were average 1 years of follow-up, no one case death and ischemic stroke occurred. Conclusion:It is safety and efficacy with using cerebral protection devices?and stent angioplasty in the treatment of patients with carotid artery stenosis and prevention?of?ischemic stroke. Keywords：?carotid artery Stenosis； cerebral protection device；?stent；?angioplasty通讯作者：迟路湘：ch126.com 卒中是一种世界范围的常见疾病，同时也是导致死亡及致残的主要原因。脑血管病连续5年为我国第二位死亡原因，其中多数为缺血性脑血管疾病（ischemic vascular cerebral disease， IVCD）。荟萃分析发现，约2%的IVCD的发生是由于颅外颈部血管的狭窄或动脉粥样硬化所致，解除颅外颈部血管的狭窄或粥样斑块破裂可明显降低患者5年内脑梗死的发生率。尽管临床随机对照研究证实了颈动脉内膜切除术（）在治疗颈动脉狭窄中的安全性有效性，但随着血管内介入治疗的开展，人们对颈动脉狭窄的干预手段又有了新的看法。近