大分割三维适形放疗联合化疗治疗Ⅲ期非小细胞肺癌疗效分析.PDFVIP

维普资讯 · 498 · 肿瘤防治研究2004年第31卷第8期 大分割三维适形放疗联合化疗治疗Ⅲ期非小 细胞肺癌疗效分析 周同冲，林晓丹，成 拯 ThreeDimensionalConformalHypofractionated Hige-doseRadiotherapyCombined with ChemotherapyforStageIllNon-small-ceIlLungCancer ZHOU Tong．chong，LIN Xiao-dan，CHENGZheng DepartmentofRadiationOncology，GuangzhouTumorHospital，Guangzhou510095，China Abstract：Objective Toexplorethecurativeeffectsandsideeffectsofthreedimensionalconforrnalhypofrac— tionatedhige-doseradiotherapy(3DCRT)combinedwithchemotherapyforstagem non—small—celllung~ncer D (NSCLC)．Methods 98patientswithStagemNSCLCweretreatdewith3DCRTandchemotherapyocncur— rently-Paclitaxe140mg／m2，CarboplatinAUC：2，onceaweek，6weekstotally；3DCRT beganfrom the D secondweekatthetotaldoseof60～66Gyinaocurseof20～24days．6～8Gyofraechfraction．Afterthat。 C twocyclesofchemotherapyofllowde：Paclitaxel135mg／m2，dl，CarboplatinAUC=5，dl，onecyclelasting 21days．Results Theoveral1responserate(CR+PR)Was82．65％ ofrtheprimarytumorand100％ ofr metastaticmdeiastinallymphnodes．The1一．2-yearsurviva1rateswere77．55％ and56．12％．The1euocpenia rateWaS94．88％ (47．96％GmdesIll，Ⅳ)．BkxxtplateletrdeuctionofGrades11，m happende in29．59％ D c ．Acuteradiationesophagitisoccurredin44．89％cases(7．14％Gradem)．Acuteradiationpneumonitis WaSobservde in11．22％ (GradesI，11)．Condusion 3DCRTcombindewithchemotherapyiseffectivefor D stagem NSCLCandthesideeffcetsa／etolerable． Keywords：ThreedimensionNocnforma1radiotherapy；Non—small—cel1lungcancer；Chemotherapy；Prognosis C 摘 要：目的 探讨大分割三维适形放疗(3DCRT)联合化疗治疗Ⅲ期非小细胞肺癌(NSCLC)的疗效和 毒副反应。方法 时98例Ⅲ期NSCLC惠者进行同期放化疗：紫杉醇40rag／m2，卡铂(Auc=2)，每周 1 次，共6周。3DCRT从第2周开始，6-