原创力文档comparison of the effectiveness of trauma-focused cognitive behavioral therapy and paroxetine treatment in ptsd patients design of a randomized controlled trial比较针对认知行为疗法的有效性和帕罗西汀治疗创伤后应激障碍患者的随机对照试验的设计.pdfVIP
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comparison of the effectiveness of trauma-focused cognitive behavioral therapy and paroxetine treatment in ptsd patients design of a randomized controlled trial比较针对认知行为疗法的有效性和帕罗西汀治疗创伤后应激障碍患者的随机对照试验的设计
Polak et al. BMC Psychiatry 2012, 12:166
/1471-244X/12/166
STUDY PROTOCOL Open Access
Comparison of the effectiveness of
trauma-focused cognitive behavioral therapy and
paroxetine treatment in PTSD patients: Design of
a randomized controlled trial
1* 1 1 2 1 1
A Rosaura Polak , Anke B Witteveen , Rogier S Visser , Brent C Opmeer , Nienke Vulink , Martijn Figee ,
Damiaan Denys1,3 and Miranda Olff1,4
Abstract
Background: The two most common interventions for Posttraumatic Stress Disorder (PTSD) are pharmacological
treatment with SSRIs such as paroxetine and psychological treatment such as Trauma-Focused Cognitive Behavioral
Therapy (TF-CBT). International guidelines recommend trauma-focused psychological interventions for all PTSD
patients as first-line treatment (NICE). However, no clear-cut evidence is available to support this recommendation.
Methods/design: In order to compare pharmacological treatment (paroxetine) and psychological treatment
(TF-CBT) in (cost-) effectiveness on the short and the long term, we will randomize 90 patients with chronic PTSD
to either paroxetine (24 weeks) or TF-CBT (10– 12 weeks). We will assess symptom severity and costs before and
after the intervention with the Clinician Administered PTSD Scale (CAPS), the Clinical Global Impression Scale (CGI)
and the Trimbos/iMTA questionnaire for Costs associated with Psychiatric Illness (TiC-P).
Discussion: This study is unique for its direct comparison of the most commonly used psychological intervention
(TF-CBT) and pharmacological intervention (paroxetine) on (cost-) effectiveness on the short and the long term.
The anticipated results will provide relevant evidence concerning long-term effects and relapse rates and will be
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