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composition influence on pulmonary delivery of rifampicin liposomes对肺的利福平脂质体组成影响
Pharmaceutics 2012, 4, 590-606; doi:10.3390/pharmaceutics4040590
OPEN ACCESS
pharmaceutics
ISSN 1999-4923
/journal/pharmaceutics
Article
Composition Influence on Pulmonary Delivery of
Rifampicin Liposomes
1 1 1 2
Maria Letizia Manca , Chiara Sinico , Anna Maria Maccioni , Octavio Diez ,
Anna Maria Fadda 1 and Maria Manconi 1,*
1 Department of Environmental and Life Science, University of Cagliari, Cagliari 09124, Italy;
E-Mails: mlmanca@unica.it (M.L.M.); sinico@unica.it (C.S.); macciom@unica.it (A.M.M.);
mfadda@unica.it (A.M.F.)
2 Department of Pharmacy and Pharmaceutical Technology, University of Valencia, Valencia
46100-Burjassot, Spain; E-Mail: octavio.diez@uv.es
* Author to whom correspondence should be addressed; E-Mail: manconi@unica.it;
Tel.: +390-706-758-542; Fax: +390-706-758-710.
Received: 18 September 2012; in revised form: 1 November 2012 / Accepted: 16 November 2012 /
Published: 27 November 2012
Abstract: The effects of lipid concentration and composition on the physicochemical
properties, aerosol performance and in vitro toxicity activity of several rifampicin-loaded
liposomes were investigated. To this purpose, six liposome formulations containing
different amounts of soy phosphatidylcholine and hydrogenated soy phosphatidylcholine,
with and without cholesterol and oleic acid, were prepared and fully characterized. Uni- or
oligo-lamellar, small (~100 nm), negatively charged
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