compounds from the roots and rhizomes of valeriana amurensis protect against neurotoxicity in pc12 cells化合物从缬草的根和根状茎amurensis防止在pc12细胞中神经毒性.pdfVIP

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compounds from the roots and rhizomes of valeriana amurensis protect against neurotoxicity in pc12 cells化合物从缬草的根和根状茎amurensis防止在pc12细胞中神经毒性.pdf

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compounds from the roots and rhizomes of valeriana amurensis protect against neurotoxicity in pc12 cells化合物从缬草的根和根状茎amurensis防止在pc12细胞中神经毒性

Molecules 2012, 17, 15013-15021; doi:10.3390/molecules171215013 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells Qiuhong Wang 1,†, Changfu Wang 1,†, Yueming Zuo 2, Zhibin Wang 1, Bingyou Yang 1 and Haixue Kuang 1,* 1 Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, No. 24 HePing Road, XiangFang District, Harbin 150040, China; E-Mails: qhwang668@ (Q.W.); wangchangfu831124@163.com (C.W.); wzbmailbox@126.com (Z.W.); ybywater@163.com (B.Y.) 2 Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China; E-Mail: zuo_yueming@163.com † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: hxkuang@; Tel.: +86-451-8219-3001; Fax: +86-451-8211-0803. Received: 12 November 2012; in revised form: 6 December 2012 / Accepted: 11 December 2012 / Published: 18 December 2012 Abstract: Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds 1–3), were isolated along with ten known compounds 4–13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of 1–3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1–13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ