原创力文档computational identification of obligatorily autocatalytic replicators embedded in metabolic networks仅计算识别催化复制器嵌入在代谢网络.pdfVIP
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computational identification of obligatorily autocatalytic replicators embedded in metabolic networks仅计算识别催化复制器嵌入在代谢网络
Volume 9, Issue 3, Article R51et al.Kun2008 Open Access
Research
Computational identification of obligatorily autocatalytic
replicators embedded in metabolic networks
Ádám Kun*†, Balázs Papp‡¶ and Eörs Szathmáry*†§
Addresses: *Collegium Budapest, Institute for Advanced Study, Szentháromság utca 2, Budapest H-1014, Hungary. †Department of Plant
Taxonomy and Ecology, Institute of Biology, Eötvös University, Pázmány Péter sétány 1/C, Budapest H-1117, Hungary. ‡Faculty of Life Sciences,
The University of Manchester, Oxford Road, Manchester M13 9PT, UK. §Parmenides Center for the Study of Thinking, Kardinal Faulhaber
Strasse, Munich D-80333, Germany. ¶Current address: Institute of Biochemistry, Biological Research Center, Szeged H-6701, Hungary.
Correspondence: Balázs Papp. Email: pappb@brc.hu
Published: 10 March 2008 Received: 26 September 2007
Revised: 5 January 2008
Genome Biology 2008, 9:R51 (doi:10.1186/gb-2008-9-3-r51)
Accepted: 10 March 2008
The electronic version of this article is the complete one and can be
found online at /2008/9/3/R51
© 2008 Kun et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
licators varies./pMetabolic autocatalytic replicatorsstudy in different organisms, revealing that in the enzymatic reactions of conserved autocatalytic cycles, the autocatalytic bepSmall-molecular metabolic autocatalytic regulators, which are crucial to metabolic pathways, are identified in a novel systehavior of
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