原创力文档computational simulation of vasopressin secretion using a rat model of the water and electrolyte homeostasis使用一只老鼠模型计算模拟抗利尿激素分泌的水和电解质内稳态.pdfVIP
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computational simulation of vasopressin secretion using a rat model of the water and electrolyte homeostasis使用一只老鼠模型计算模拟抗利尿激素分泌的水和电解质内稳态
Nadeau et al. BMC Physiology 2010, 10:17
/1472-6793/10/17
RESEARCH ARTICLE Open Access
Computational simulation of vasopressin
secretion using a rat model of the water and
electrolyte homeostasis
*
Louis Nadeau, Danielle Arbour, Didier Mouginot
Abstract
Background: In mammals, vasopressin (AVP) is released from magnocellular neurons of the hypothalamus when
osmotic pressure exceeds a fixed set-point. AVP participates to the hydromineral homeostasis (HH) by controlling
water excretion at the level of the kidneys. Our current understanding of the HH and AVP secretion is the result of
a vast amount of data collected over the five past decades. This experimental data was collected using a number
of systems under different conditions, giving a fragmented view of the components involved in HH.
Results: Here, we present a high-level model of the rat HH based on selected published results to predict short-
term (hours) to long-term (days) variation of six major homeostatic parameters: (1) the extracellular sodium
concentration, (2) the AVP concentration, (3) the intracellular volume, (4) the extracellular volume, (5) the urine
volume and (6) the water intake. The simulation generates quantitative predictions like the daily mean of the
extracellular sodium concentration (142.2 mmol/L), the AVP concentration, (1.7 pg/ml), the intracellular volume
(45.3 ml/100 g body weight - bw), the extracellular volume (22.6 ml/100 g bw), the urine volume (11.8 ml/100 g
bw) and the cumulative water intake (18 ml/100 g bw). The simulation also computes the dynamics of all these
parameters with a high temporal resolution of one minute. This high resolution predicts the circadian fluctuation
of the AVP secretion (5 ± 2 pg/ml) and defines the limits of a restoration and a maintenance pha
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