原创力文档compartmentalization of lipid peroxidation in sepsis by multidrug-resistant gram-negative bacteria experimental and clinical evidence划分的脂质过氧化作用由耐多药革兰氏阴性细菌败血症实验和临床证据.pdfVIP
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compartmentalization of lipid peroxidation in sepsis by multidrug-resistant gram-negative bacteria experimental and clinical evidence划分的脂质过氧化作用由耐多药革兰氏阴性细菌败血症实验和临床证据
Toufekoula et al. Critical Care 2013, 17:R6
/content/17/1/R6
RESEARCH Open Access
Compartmentalization of lipid peroxidation in
sepsis by multidrug-resistant gram-negative
bacteria: experimental and clinical evidence
1 1 1 2 3
Chryssoula Toufekoula , Vassileios Papadakis , Thomas Tsaganos , Christina Routsi , Stylianos E Orfanos ,
2 1 1 1
Anastasia Kotanidou , Dionyssia-Pinelopi Carrer , Maria Raftogiannis , Fotini Baziaka and
Evangelos J Giamarellos-Bourboulis1,4*
Abstract
Introduction: Recent evidence suggests a link between excess lipid peroxidation and specific organ failures in
sepsis. No study has been performed in sepsis by multidrug-resistant (MDR) Gram-negative bacteria.
Methods: Lethal sepsis was induced in rats by the intraperitoneal injection of one MDR isolate of Pseudomonas
aeruginosa. Produced malondialdehyde (MDA) was measured in tissues 5 hours after bacterial challenge with the
thiobarbiturate assay followed by high-performance liquid chromatography (HPLC) analysis. Results were compared
with those from a cohort of patients with ventilator-associated pneumonia (VAP) and sepsis by MDR Gram-
negative bacteria. More precisely, serum MDA was measured on 7 consecutive days, and it was correlated with
clinical characteristics.
Results: MDA of septic rats was greater in the liver, spleen, and aortic wall, and it was lower in the right kidney
compared with sham operated-on animals. Findings were confirmed by the studied cohort. Circulating MDA was
greater in patients with hepatic dysfunction and acute respiratory distress syndrome (ARDS) compared with
patients without any
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