consistent probabilistic outputs for protein function prediction蛋白质功能预测概率输出一致.pdfVIP

Volume 9, Suppl 1, Article S6et al.Obozinski2008 Open Access Method Consistent probabilistic outputs for protein function prediction * † ‡ § Guillaume Obozinski , Gert Lanckriet , Charles Grant , Michael I Jordan and William Stafford Noble¶ Addresses: *Department of Statistics University of California, Berkeley, Berkeley, CA 94720, USA. †Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, CA 92093, USA. ‡Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. §Department of Statistics, Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA 94720, USA. ¶Department of Genome Sciences, Department of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA. Correspondence: William Stafford Noble. Email: noble@ Published: 27 June 2008 Genome Biology 2008, 9:S6 The electronic version of this article is the complete one and can be found online at /2008/9/S1/S6 © 2008 Obozinski et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract In predicting hierarchical protein function annotations, such as terms in the Gene Ontology (GO), the simplest approach makes predictions for each term independently. However, this approach has the unfortunate consequence that the predictor may assign to a single protein a set of terms that are inconsistent with one another; for example, t