on corticosteroid therapy for severe lupus encephalopathy one case（对皮质类固醇治疗严重的红斑狼疮脑病1例）.docVIP

On corticosteroid therapy for severe lupus encephalopathy one case Systemic lupus erythematosus (SLE is a representative multi-system, multi-organ involvement in systemic autoimmune connective tissue disease, autoimmune disease is the prototype for self-reactive T, B lymphocytes over-intensification of inflammatory cells factor imbalance and large variety of autoantibodies produced as the main immunological features its typical characteristics of polyclonal B cell activation and a variety of autoantibodies, the current etiology and pathogenesis is unclear. many parts of the nervous system can be accumulated , SLE is more common in the central nervous system damage to parts of the clinical performance of diversity, pathogenesis may include: immune complex-mediated cerebral vasculitis, antibody-mediated endothelial cell damage and platelet dysfunction, cardiac superfluous organisms caused by intracranial vascular thrombosis, etc. lupus encephalopathy, central nervous system damage in SLE is of critical illness, acute fulminant SLE is a clinical difference between the treatment of lupus encephalopathy, mortality is high, I encountered severe lupus encephalopathy in 1 case, reported as follows: Clinical data Patients: Female, 39 years old, due to edema, hair loss, joint pain 1 month, fever for 1 week at 14 September 2001 admission. In the 11 months before there is no clear incentive to systemic edema, oliguria, this treatment in local hospital, diagnosed as “nephrotic syndrome”, and symptomatic treatment given oral prednisone after 2 months, no significant effect of private prosecution, discharge and withdrawal. pathogenesis of significant hair loss, and joint pain and malaise, mouth dry eye In recent year, oral medicine, treatment, puffy when light weight. nearly one week of fever, low to moderate heat. Since the onset after the sun had facial swelling. physical examination: blood pressure 150/90mmHg, cheeks Department of butterfly erythema, light red, the surfac