卡托普利及snp对vsmc中et-1释放的作用（Effects of Kato Pury and SNP on the release of ET-1 in VSMC）.docVIP

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卡托普利及snp对vsmc中et-1释放的作用（Effects of Kato Pury and SNP on the release of ET-1 in VSMC）.doc

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卡托普利及snp对vsmc中et-1释放的作用（Effects of Kato Pury and SNP on the release of ET-1 in VSMC）

卡托普利及snp对vsmc中et-1释放的作用（Effects of Kato Pury and SNP on the release of ET-1 in VSMC） The role of Kato Pury and SNP on the release of ET-1 in VSMC 2010-01-14 steel Zhou Lijuan Song Yu Ma Xianghong Cong Junan luteal Wang Wei Liu Hongmei [Abstract] Objective To investigate the influence of Kato Pury and SNP on the release of ET-1 in cultured rat VSMC and their relationship. Methods cultured in different concentrations of captopril and / or implantation of SNP in rats after VSMC, ET-1 was determined by radioimmunoassay. The results of Kato Pury and SNP can reduce by Ang II cause endothelial VSMC secretion levels, Ang levels and VSMC II ET-1 secretion was positively correlated. Conclusion ET-1 VSMC by inhibiting the production of endogenous NO to accelerate the occurrence and development of AS, ACEI or NO inhibited the release of ET-1, can reduce the formation of AS. [Key words] Kato Pury sodium nitroprusside endothelial nitric oxide vascular smooth muscle cells The releasing effected of captopril and sodium nitroprusside on endothelin-1 in vascular smooth muscle cell Cong Hongliang, Huang Tigang, Zhou Lijuan, et al. Tianjin Cardiovascular Institute, Tianjin 300211 [Abstract] Objective Investigating the influence of captopril and SNP on releasing ET-1 in cultured VSMC of rat. Methods Measuring the endothelin-1 level through radioimmunology assay in various concentration of captopril and/or sodium nitroprusside in cultured vascular smooth muscle cell of rat. Results The results show that both captopril and SNP could reducing the high ET-1 level of VSMC which were caused by Ang There were a linear relationship 2. Between Ang level and ET-1 production II (r=0.760 1, P 0.001).Conclusion Endothelin-1 maybe accelerating the atherosclerosis formation and developing through inhibiting endogenous NO produced by VSMC. ACEI or NO, inhibiting ET-1 release, may reduce atherosclerosis formation. [Key] words Captopril Sodium nitroprusside Endothelin-1 Nitric oxide Vascular smooth musc