吲达帕胺片说明书（Indapamide Tablets manual）.docVIP

吲达帕胺片说明书（Indapamide Tablets manual） Indapamide Tablets Instructions [general name] Indapamide Tablets [English name] [ingredients] indapamide. Chemical name: N- (2- methyl -2, 3- two -1H- hydrogen indolyl) -3- sulfamoyl -4- chloro - benzamide. [property] this product is sugar coated tablets, after removing sugar coated, showing white. [action category] [pharmacological toxicology] is a sulfonamide diuretic that acts by inhibiting the reabsorption of water and electrolytes in the distal segment of the renal tubular cortex. The antihypertensive effect is unknown, the diuretic effect can not be explained by antihypertensive effect, antihypertensive effect appears far less than the dose of diuretic dose, the possible mechanisms include the following aspects: the regulation of vascular smooth muscle cells calcium influx; stimulate the synthesis of prostaglandin PGE2 and prostaglandin PGI2; reduction of vascular compression on vascular amine hypersensitivity, thereby inhibiting vascular contraction. This product has little or no effect on cardiac output, heart rate, and rhythm of the heart when lowering blood pressure. Long term use of this product rarely affects glomerular filtration rate or renal blood flow. This medicine does not affect the metabolism of blood lipids and carbohydrates. [pharmacokinetics] oral absorption was rapid and complete, with a bioavailability of 93% without food impact. Plasma binding rate was 71 to 79%, and it was also combined with elastin of vascular smooth muscle. Serum concentration peaked at 1~2 hours after oral administration. Oral administration of a single agent after about 24 hours reached a peak hypotensive effect; repeated delivery of about 8~12 weeks up to the peak role, the effect of 8 weeks. The half-life is 14~18 hours. Metabolism in the liver produces 19 metabolites. About 70% pass through the kidney, 7% of which are the original and 23% are excreted through the stomach and intestines. The pharmacokinetic parameters did not chan