原创力文档17β-estradiol is required for the sexually dimorphic effects of repeated binge-pattern alcohol exposure on the hpa axis during adolescence17β-estradiol需要重复的性别差异影响binge-pattern酒精暴露在hpa轴在青春期.pdfVIP
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17β-estradiol is required for the sexually dimorphic effects of repeated binge-pattern alcohol exposure on the hpa axis during adolescence17β-estradiol需要重复的性别差异影响binge-pattern酒精暴露在hpa轴在青春期
17b-Estradiol Is Required for the Sexually Dimorphic
Effects of Repeated Binge-Pattern Alcohol Exposure on
the HPA Axis during Adolescence
Magdalena M. Przybycien-Szymanska, Roberta A. Gillespie, Toni R. Pak*
Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, United States of America
Abstract
Alcohol consumption during adolescence has long-term sexually dimorphic effects on anxiety behavior and mood
disorders. We have previously shown that repeated binge-pattern alcohol exposure increased the expression of two critical
central regulators of stress and anxiety, corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP), in
adolescent male rats. By contrast, there was no effect of alcohol on these same genes in adolescent females. Therefore, we
tested the hypothesis that 17b-estradiol (E2), the predominant sex steroid hormone in females, prevents alcohol-induced
changes in CRH and AVP gene expression in the paraventricular nucleus (PVN) of the hypothalamus. To test this hypothesis,
postnatal day (PND) 26 females were ovariectomized and given E2 replacement or cholesterol as a control. Next, they were
given an alcohol exposure paradigm of 1) saline alone, 2) acute (single dose) or 3) a repeated binge-pattern. Our results
showed that acute and repeated binge-pattern alcohol treatment increased plasma ACTH and CORT levels in both E2- and
Ch-treated groups, however habituation to repeated binge-pattern alcohol exposure was evident only in E2-treated animals.
Further, repeated binge-pattern alcohol exposure significantly decreased CRH and AVP mRNA in Ch-, but not E2-treated
animals, which was consistent with our previous observations in gonad intact females. We further tested the effects of E2
and alcohol treatment on the activity
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