a bayesian algorithm for functional mapping of dynamic complex traits贝叶斯算法功能映射的动态复杂的特征.pdfVIP

Algorithms 2009, 2, 667-691; doi:10.3390/a2020667 OPEN ACCESS algorithms ISSN 1999-4893 /journal/algorithms Article A Bayesian Algorithm for Functional Mapping of Dynamic Complex Traits Tian Liu and Rongling Wu Department of Statistics, University of Florida, Gainesville, FL 32611 USA; E-Mail: liut2@.sg (T.L.) Genome Institute of Singapore, 60 Biopolis Street 02-01 Genome, Singapore Department of Public Health Sciences, Pennsylvania State College of Medicine, Hershey, PA 17033 USA Department of Statistics, Pennsylvania State University, University Park, PA 16802 USA Author to whom correspondence should be addressed; E-Mail:rwu@ Received: 8 January 2009; in revised form: 6 March 2009 / Accepted: 24 March 2009 / Published: 21 April 2009 Abstract: Functional mapping of dynamic traits measured in a longitudinal study was orig- inally derived within the maximum likelihood (ML) context and implemented with the EM algorithm. Although ML-based functional mapping possesses many favorable statistical prop- erties in parameter estimation, it may be computationally intractable for analyzing longitudi- nal data with high dimensions and high measurement errors. In this article, we derive a general functional mapping framework for quantitative trait locus mapping of dynamic traits within the Bayesian paradigm. Markov chain Monte Carlo techniques were implemented for func- tional mapping to estimate biologically and statistically sensible parameters that model the structures of time-dependent genetic effects and covariance matrix. The Bayesian approach is useful to