a comparative analysis of polyfunctional t cells and secreted cytokines induced by bacille calmette-guérin immunisation in children and adults比较分析的多官能的t细胞和分泌细胞因子诱导卡介苗免疫接种的儿童和成人.pdfVIP

A Comparative Analysis of Polyfunctional T Cells and ´ Secreted Cytokines Induced by Bacille Calmette-Guerin Immunisation in Children and Adults 1,2,3 1,2 1,2 2 1,2,3 Nicole Ritz *, Madeleine Strach , Carmen Yau , Binita Dutta , Marc Tebruegge , 1,2,3 4 5,7 1,2,6 1,2,3 Tom G. Connell , Willem A. Hanekom , Warwick J. Britton , Roy Robins-Browne , Nigel Curtis 1 Department of Paediatrics, The University of Melbourne, Parkville, Australia, 2 Murdoch Children’s Research Institute, Parkville, Australia, 3 Infectious Diseases Unit, Department of General Medicine, The Royal Children’s Hospital Melbourne, Parkville, Australia, 4 South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa, 5 Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, Camperdown Australia, 6 Department of Microbiology and Immunology, The University of Melbourne, Parkville, Australia, 7 Department of Medicine, University of Sydney, Camperdown Australia Abstract BCG vaccine is one of the most commonly-administered vaccines worldwide. Studies suggest the protective efficacy of BCG against TB is better for children than for adults. One potential explanation is that BCG induces a better protective immune response in children. Twenty si