a comparative study of gene-expression data of basal cell carcinoma and melanoma reveals new insights about the two cancers比较基底细胞癌、黑色素瘤的基因表达数据的研究揭示了关于两种癌症的新见解.pdfVIP

A Comparative Study of Gene-Expression Data of Basal Cell Carcinoma and Melanoma Reveals New Insights about the Two Cancers 1,2 1 1,3 1 1 1,4 Kun Xu , Xizeng Mao , Minesh Mehta , Juan Cui , Chi Zhang , Ying Xu * 1 Department of Biochemistry and Molecular Biology and Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America, 2 Department of Statistics, University of Georgia, Athens, Georgia, United States of America, 3 College of Medicine, American University of Antigua, New York, New York, United States of America, 4 College of Computer Science and Technology, Jilin University, Changchun, Jilin, China Abstract A comparative analysis of genome-scale transcriptomic data of two types of skin cancers, melanoma and basal cell carcinoma in comparison with other cancer types, was conducted with the aim of identifying key regulatory factors that either cause or contribute to the aggressiveness of melanoma, while basal cell carcinoma generally remains a mild disease. Multiple cancer-related pathways such as cell proliferation, apoptosis, angiogenesis, cell invasion and metastasis, are considered, but our focus is on energy metabolism, cell invasion and metastasis pathways. Our findings include the following. (a) Both types of skin cancers use both glycolysis and increased oxidative phosphorylation (electron transfer chain) for their energy supply. (b) Advanced melanoma shows substantial up-regulation of key genes involved in fatty acid metabolism (b-oxidation) and oxidative phosphorylation, with aerobic metabolism being far more efficient than anaerobic glycolysis, providing a source of the energetics necessary to support the rapi