原创力文档a model of repetitive-dna-organized chromatin network of interphase chromosomesrepetitive-dna-organized染色质网络间期染色体的典范.pdfVIP
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a model of repetitive-dna-organized chromatin network of interphase chromosomesrepetitive-dna-organized染色质网络间期染色体的典范
Genes 2012, 3, 167-175; doi:10.3390/genes3010167
OPEN ACCESS
genes
ISSN 2073-4425
/journal/genes
Opinion
A Model of Repetitive-DNA-Organized Chromatin Network of
Interphase Chromosomes †
Shao-Jun Tang
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston,
TX 77555, USA; E-Mail: shtang@; Tel.: +1-409-772-1190
† The author dedicates this paper to Professor Liangshi Liu.
Received: 14 January 2012; in revised form: 21 February 2012 / Accepted: 28 February 2012 /
Published: 7 March 2012
Abstract: During interphase, chromosomes are relatively de-condensed in the nuclear space.
Interphase chromosomes are known to occupy nuclear space in a non-random manner
(chromosome territory); however, their internal structures are poorly defined. In particular,
little is understood about the molecular mechanisms that govern the internal organization
of interphase chromosomes. The author recently proposed that pairing (or interaction) of
repetitive DNA-containing chromatin regions is a critical driving force that specifies the
higher-order organization of eukaryotic chromosomes. Guided by this theoretical framework
and published experimental data on the structure of interphase chromosomes and the spatial
distribution of repetitive DNA in interphase nuclei, I postulate here a molecular structure of
chromatin organization in interphase chromosomes. According to this model, an interphase
chromosome is a chromatin mesh (or lattice) that is formed by repeat p
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