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a digitally controllable polymer-based microfluidic mixing module array一个数字可控聚合物微流体混合模块数组.pdf

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a digitally controllable polymer-based microfluidic mixing module array一个数字可控聚合物微流体混合模块数组

Micromachines 2012, 3, 279-294; doi:10.3390/mi3020279 OPEN ACCESS micromachines ISSN 2072-666X /journal/micromachines Article A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array Raymond H. W. Lam * and Wen J. Li * Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong, China * Authors to whom correspondence should be addressed; E-Mails: rhwlam@.hk (R.H.W.L.); wenjli@.hk (W.J.L.); Tel.: +852-3442-8577 (R.H.W.L.); Tel.: +852-3442-9266 (W.J.L.); Fax: +852-3442-0172. Received: 11 February 2012; in revised form: 15 March 2012 / Accepted: 27 March 2012 / Published: 29 March 2012 Abstract: This paper presents an integrated digitally controllable microfluidic system for continuous solution supply with a real-time concentration control. This system contains multiple independently operating mixing modules, each integrated with two vortex micropumps, two Tesla valves and a micromixer. The interior surface of the system is made of biocompatible materials using a polymer micro-fabrication process and thus its operation can be applied to chemicals and bio-reagents. In each module, pumping of fluid is achieved by the vortex micropump working with the rotation of a micro-impeller. The downstream fluid mixing is based on mechanical vibrations driven by a lead zirconate titanate ceramic diaphragm actuator located below the mixing chamber. We have conducted experiments t