a multi-functional synthetic gene network a frequency multiplier, oscillator and switch一个多功能合成基因网络一个倍频器,振荡器和开关.pdfVIP

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a multi-functional synthetic gene network a frequency multiplier, oscillator and switch一个多功能合成基因网络一个倍频器,振荡器和开关.pdf

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a multi-functional synthetic gene network a frequency multiplier, oscillator and switch一个多功能合成基因网络一个倍频器,振荡器和开关

A Multi-Functional Synthetic Gene Network: A Frequency Multiplier, Oscillator and Switch 1 2,3 4 5 Oliver Purcell *, Mario di Bernardo , Claire S. Grierson , Nigel J. Savery 1 Department of Engineering Mathematics, Bristol Centre for Complexity Sciences, University of Bristol, Bristol, United Kingdom, 2 Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom, 3 Department of Systems and Computer Engineering, University of Naples Federico II, Napoli, Italy, 4 School of Biological Sciences, University of Bristol, Bristol, United Kingdom, 5 School of Biochemistry, University of Bristol, Bristol, United Kingdom Abstract We present the design and analysis of a synthetic gene network that performs frequency multiplication. It takes oscillatory transcription factor concentrations, such as those produced from the currently available genetic oscillators, as an input, and produces oscillations with half the input frequency as an output. Analysis of the bifurcation structure also reveals novel, programmable multi-functionality; in addition to functioning as a frequency multiplier, the network is able to function as a switch or an oscillator, depending on the temporal nature of the input. Multi-functionality is often observed in neuronal networks, where it is suggested to allow for the efficient coordination of different responses. This network represents a significant theoretical addition that extends the capabilities of synthetic gene networks. Citation: Purcell O, di Bernardo M, Grierson CS, Savery NJ (2011) A Multi-Functional Synthetic Gene Network: A Frequency Multiplier, Oscillator and Switch. PLoS ONE 6(2): e16140. doi:10.1371/journal.pone.0016140 Editor: Jean Peccoud, Virginia Tech, United States of America Receive