a fine-mapping study of 7 top scoring genes from a gwas for major depressive disorder进球最多7基因的精细定位研究从gwas重度抑郁症.pdfVIP

A Fine-Mapping Study of 7 Top Scoring Genes from a GWAS for Major Depressive Disorder 1 . 1. 1 ´ 1 1 Eva C. Verbeek * , Ingrid M. C. Bakker , Marianna R. Bevova , Zoltan Bochdanovits , Patrizia Rizzu , 1 3 3 2 2,4,5 David Sondervan , Gonneke Willemsen , Eco J. de Geus , Johannes H. Smit , Brenda W. Penninx , Dorret I. Boomsma3, Witte J. G. Hoogendijk2,6, Peter Heutink1 1 Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands, 2 Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, 3 Department of Biological Psychology, VU University Medical Center, Amsterdam, The Netherlands, 4 Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands, 5 Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands, 6 Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands Abstract Major depressive disorder (MDD) is a psychiatric disorder that is characterized -amongst others- by persistent depressed mood, loss of interest and pleasure and psychomotor retardation. Environmental circumstances have proven to influence the aetiology of the disease, but MDD also has an estimated 40% heritability, probably with a polygenic background. In 2009, a genome wide association study (GWAS) was performed on the Dutch GAIN-MDD cohort. A non-synonymous coding single nucleotide polymorphism (SNP) rs2522833 in the PCLO gene became only nominally significant after post-hoc analysis with an Australian cohort