a nonparametric test reveals selection for rapid flowering in the arabidopsis genome非参数测试表明选择快速开花在拟南芥基因组中.pdfVIP
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a nonparametric test reveals selection for rapid flowering in the arabidopsis genome非参数测试表明选择快速开花在拟南芥基因组中
PLoS BIOLOGY
A Nonparametric Test Reveals Selection
for Rapid Flowering in the Arabidopsis Genome
1* 1 ´ 1¤ 2 1 1
Christopher Toomajian , Tina T. Hu , Maria Jose Aranzana , Clare Lister , Chunlao Tang , Honggang Zheng ,
1 1 2 1
Keyan Zhao , Peter Calabrese , Caroline Dean , Magnus Nordborg
1 Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States of America, 2 Department of Cell and Developmental
Biology, John Innes Centre, Norwich Research Park, Colney, Norwich, United Kingdom
The detection of footprints of natural selection in genetic polymorphism data is fundamental to understanding the
genetic basis of adaptation, and has important implications for human health. The standard approach has been to
reject neutrality in favor of selection if the pattern of variation at a candidate locus was significantly different from the
predictions of the standard neutral model. The problem is that the standard neutral model assumes more than just
neutrality, and it is almost always possible to explain the data using an alternative neutral model with more complex
demography. Today’s wealth of genomic polymorphism data, however, makes it possible to dispense with models
altogether by simply comparing the pattern observed at a candidate locus to the genomic pattern, and rejecting
neutrality if the pattern is extreme. Here, we utilize this approach on a truly genomic scale, comparing a candidate
locus to thousands of alleles throughout the Arabidopsis thal
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