amitriptyline-mediated cognitive enhancement in aged 3×tg alzheimers disease mice is associated with neurogenesis and neurotrophic activityamitriptyline-mediated认知增强3×岁tg阿尔茨海默病小鼠神经发生和神经营养活性相关联.pdfVIP

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2017-09-07 发布于上海
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amitriptyline-mediated cognitive enhancement in aged 3×tg alzheimers disease mice is associated with neurogenesis and neurotrophic activityamitriptyline-mediated认知增强3×岁tg阿尔茨海默病小鼠神经发生和神经营养活性相关联.pdf

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amitriptyline-mediated cognitive enhancement in aged 3×tg alzheimers disease mice is associated with neurogenesis and neurotrophic activityamitriptyline-mediated认知增强3×岁tg阿尔茨海默病小鼠神经发生和神经营养活性相关联

Amitriptyline-Mediated Cognitive Enhancement in Aged 3 6Tg Alzheimer’s Disease Mice Is Associated with Neurogenesis and Neurotrophic Activity 1 2 3 1 1 1 Wayne Chadwick , Nick Mitchell , Jenna Caroll , Yu Zhou , Sung-Soo Park , Liyun Wang , Kevin G. 4 4 4 4 5 1 Becker , Yongqing Zhang , Elin Lehrmann , William H. Wood III , Bronwen Martin , Stuart Maudsley * 1 Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America, 2 Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America, 3 Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 4 Genomics Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America, 5 Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America Abstract Approximately 35 million people worldwide suffer from Alzheimer’s disease (AD). Existing therapeutics, while moderately effective, are currently unable to stem the widespread rise in AD prevalence. AD is associated with an increase in amyloid beta (Ab) oligomers and hyperphosphorylated tau, along with cognitive impairment and neurodegeneration. Several antidepressants have shown promise in improving cognition and alleviating oxidative stress in AD but have failed as long- term therapeutics. In this study, amitriptyline, an FDA-approved tricyclic antide