原创力文档amniotic-fluid–derived mesenchymal stem cells overexpressing interleukin-1 receptor antagonist improve fulminant hepatic failureamniotic-fluid-derived间充质干细胞overexpressing interleukin-1受体拮抗剂改善暴发性肝衰竭.pdfVIP
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amniotic-fluid–derived mesenchymal stem cells overexpressing interleukin-1 receptor antagonist improve fulminant hepatic failureamniotic-fluid-derived间充质干细胞overexpressing interleukin-1受体拮抗剂改善暴发性肝衰竭
Amniotic-Fluid–Derived Mesenchymal Stem Cells
Overexpressing Interleukin-1 Receptor Antagonist
Improve Fulminant Hepatic Failure
1,2 1 1 1 1 1
Yu-Bao Zheng , Xiao-Hong Zhang , Zhan-Lian Huang , Chao-Shuang Lin , Jing Lai , Yu-Rong Gu , Bin-
1 1 1 1 1,2
Liang Lin , Dong-Ying Xie , Shi-Bin Xie , Liang Peng , Zhi-Liang Gao *
1 Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou City, People’s Republic of China, 2 Key Laboratory of Tropical
Disease Control, Sun Yat-Sen University, Ministry of Education, Gangding, Guangzhou City, People’s Republic of China
Abstract
Uncontrolled hepatic immunoactivation is regarded as the primary pathological mechanism of fulminant hepatic failure
(FHF). The major acute-phase mediators associated with FHF, including IL-1b, IL-6, and TNF-a, impair the regeneration of
liver cells and stem cell grafts. Amniotic-fluid–derived mesenchymal stem cells (AF-MSCs) have the capacity, under specific
conditions, to differentiate into hepatocytes. Interleukin-1–receptor antagonist (IL-1Ra) plays an anti-inflammatory and anti-
apoptotic role in acute and chronic inflammation, and has been used in many experimental and clinical applications. In the
present study, we implanted IL-1Ra–expressing AF-MSCs into injured liver via the portal vein, using D-galactosamine–
induced FHF in a rat model. IL-1Ra expression, hepatic injury, liver regeneration, cytokines (IL-1b, IL-6), and animal survival
were assessed after cell transplantation. Our results showed that AF-MSCs over-expressing IL-1Ra prevented liver fai
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