anaesthetic impairment of immune function is mediated via gabaa receptors麻醉损伤的免疫功能是通过gabaa受体介导的.pdfVIP

Anaesthetic Impairment of Immune Function Is Mediated via GABAA Receptors 1 2 1 3 1 Daniel W. Wheeler , Andrew J. Thompson , Federico Corletto , Jill Reckless , Justin C. T. Loke , Nicolas 4 5 5 3 2 6 Lapaque , Andrew J. Grant , Pietro Mastroeni , David J. Grainger , Claire L. Padgett , John A. O’Brien , 4 4 2,6 . 1. 1. Nigel G. A. Miller , John Trowsdale , Sarah C. R. Lummis * , David K. Menon , John S. Beech 1 Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom, 2 Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom, 3 Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom, 4 Department of Pathology, University of Cambridge, Cambridge, United Kingdom, 5 Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom, 6 Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom Abstract Background: GABAA receptors are members of the Cys-loop family of neurotransmitter receptors, proteins which are responsible for fast synaptic transmission, and are the site of action of wide range of drugs [1]. Recent work has shown that Cys-loop receptors are present on immune cells, but their physiological roles and the effects of drugs that modify their function in the innate immune system are currently un