原创力文档amino acids transitioning of 2009 h1n1pdm in taiwan from 2009 to 2011氨基酸转变2009 h1n1pdm台湾从2009年到2011年.pdfVIP
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amino acids transitioning of 2009 h1n1pdm in taiwan from 2009 to 2011氨基酸转变2009 h1n1pdm台湾从2009年到2011年
Amino Acids Transitioning of 2009 H1N1pdm in Taiwan
from 2009 to 2011
1,2. 2,3,6 . 2,3,6 5
Guang-Wu Chen , Kuo-Chien Tsao * , Chung-Guei Huang , Yu-Nong Gong , Shih-
2,3 6 6 6 2,4,7 4,7
Cheng Chang , Yi-Chun Liu , Hsiao-Han Wu , Shu-Li Yang , Tzou-Yien Lin , Yhu-Chering Huang ,
Shin-Ru Shih2,3,6
1 Department of Computer Science and Information Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China, 2 Research Center for Emerging Viral
Infections, Chang Gung University, Taoyuan, Taiwan, Republic of China, 3 Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan,
Taiwan, Republic of China, 4 College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China, 5 Graduate Institute of Electrical Engineering, Chang Gung
University, Taoyuan, Taiwan, Republic of China, 6 Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, Republic of China,
7 Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, Republic of China
Abstract
A swine-origin influenza A was detected in April 2009 and soon became the 2009 H1N1 pandemic strain (H1N1pdm). The
current study revealed the genetic diversity of H1N1pdm, based on 77 and 70 isolates which we collected, respectively,
during the 2009/2010 and 2010/2011 influenza seasons in Taiwan. We focused on tracking the amino acid transitioning of
hemagglutinin (HA) and neuraminidase (NA) genes in the early diversification of the virus and compared them with
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