an shrna-based screen of splicing regulators identifies sfrs3 as a negative regulator of il-1β secretionshrna-based屏幕拼接监管机构标识sfrs3 il-1β分泌的消极的监管机构.pdfVIP
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an shrna-based screen of splicing regulators identifies sfrs3 as a negative regulator of il-1β secretionshrna-based屏幕拼接监管机构标识sfrs3 il-1β分泌的消极的监管机构
An shRNA-Based Screen of Splicing Regulators Identifies
SFRS3 as a Negative Regulator of IL-1b Secretion
1. 1. 1. 1 1
Pedro Moura-Alves , Ana Neves-Costa , Helena Raquel , Teresa Raquel Pacheco , Bruno D’Almeida ,
1 1 ˆ 1 2 2,3
Raquel Rodrigues , Iris Cadima-Couto , Angelo Chora , Mariana Oliveira , Margarida Gama-Carvalho ,
4,5 1
Nir Hacohen , Luis F. Moita *
´
1 Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, 2 Centro de Biodiversidade, Genomica Funcional e Integrativa
ˆ
(BioFIG), Faculdade de Ciencias, Universidade de Lisboa, Lisboa, Portugal, 3 Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, 4 Division of Rheumatology,
Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United
States of America, 5 Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Abstract
The generation of diversity and plasticity of transcriptional programs are key components of effective vertebrate immune
responses. The role of Alternative Splicing has been recognized, but it is underappreciated and poorly understood as a
critical mechanism for the regulati
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