analysis and prediction of translation rate based on sequence and functional features of the mrna基于序列分析和预测的翻译速度和信使rna的功能特性.pdfVIP

Analysis and Prediction of Translation Rate Based on Sequence and Functional Features of the mRNA 1,2. 3. 4 5 2 6 Tao Huang , Sibao Wan , Zhongping Xu , Yufang Zheng , Kai-Yan Feng , Hai-Peng Li *, Xiangyin Kong4,7*, Yu-Dong Cai8,9* 1 Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China, 2 Shanghai Center for Bioinformation Technology, Shanghai, People’s Republic of China, 3 Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, People’s Republic of China, 4 Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China, 5 Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China, 6 CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China, 7 State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, People’s Republic of China, 8 Institute of Systems Biology, Shanghai University, Shanghai, People’s Republic of China, 9 Centre for Computational Systems Biology, Fudan University, Shanghai, People’s Republic of China Abstract Protein concentrations depend not only on the mRNA level, but also on the translation rate and the degradation rate. Prediction of mRNA’s translation rate would provide valuable information for in-depth understanding of the translation mechanism and dynamic proteome. In this study, we developed a new computational model to predic