anticancer activity evaluation of kuanoniamines a and c isolated from the marine sponge oceanapia sagittaria, collected from the gulf of thailand抗癌活性评价kuanoniamines a和c分离海洋海绵oceanapia sagittaria,来自泰国湾.pdfVIP

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anticancer activity evaluation of kuanoniamines a and c isolated from the marine sponge oceanapia sagittaria, collected from the gulf of thailand抗癌活性评价kuanoniamines a和c分离海洋海绵oceanapia sagittaria,来自泰国湾.pdf

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anticancer activity evaluation of kuanoniamines a and c isolated from the marine sponge oceanapia sagittaria, collected from the gulf of thailand抗癌活性评价kuanoniamines a和c分离海洋海绵oceanapia sagittaria,来自泰国湾

Mar. Drugs 2007, 5, 6-22 Marine Drugs ISSN 1660-3397 © 2007 by MDPI /marinedrugs Full Original Paper Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand Anake Kijjoa 1,2,*, Rawiwan Wattanadilok 2,3, Nair Campos 2, Maria São José Nascimento 4, 4 5 Madalena Pinto and Werner Herz 1 ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4099-003 Porto, Portugal 2 Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal 3 Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand 4 Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto (CEQOFFUP), Faculdade de Farmácia, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal 5 Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, FL 32306-4390, USA * Author to whom correspondence should be addressed; Email: ankijjoa@icbas.up.pt Received: 26 March 2007 / Accepted: 4 April 2007 / Published: 17 April 2007 Abstract: The pyridoacridine alkaloids kuanoniamines A and C were isolated together with 24α-methylcholestanol, p -hydroxybenzaldehyde, p -hydroxybenzoic acid, phenylacetic acid and 3-formylindole from the ethyl acetate extract of the marine sponge Oceanapia sagittaria (Sollas), collected from the Gulf of Thailand. Kuanoniamines A and C were