quantitative 3.0t mr spectroscopy reveals decreased creatine concentration in the dorsolateral prefrontal cortex of patients with social anxiety disorder定量3.0 t磁共振光谱揭示了肌酸浓度降低社交焦虑障碍患者的背外侧前额叶皮层.pdfVIP

Quantitative 3.0T MR Spectroscopy Reveals Decreased Creatine Concentration in the Dorsolateral Prefrontal Cortex of Patients with Social Anxiety Disorder 1. 1. 2 1 3 2 1 Qiang Yue , Mengqi Liu , Xiaojing Nie , Qizhu Wu , Jun Li , Wei Zhang *, Xiaoqi Huang , Qiyong Gong1* 1 Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, People’s Republic of China, 2 Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, People’s Republic of China, 3 Department of geriatrics, West China Hospital of Sichuan University, Chengdu, People’s Republic of China Abstract Background: The brain biochemical changes of social anxiety have not been clarified although there have been a limited number of MR spectroscopic studies which utilized metabolite/creatine ratios. Present study aimed to explore the alteration of absolute metabolite concentration in social anxiety disorder using quantitative MR spectroscopy. Materials and Methods: With a 3.0T MR scanner, single voxel MR spectroscopy (stimulated echo acquisition mode, TR/TE/ TM = 2000/20/16 ms) was performed in the left dorsolateral prefrontal cortex and related regions of nine medication-free patients with social anxiety disorder and nine controls. Absolute metabolite concentration was calculated using tissue water as the internal reference and corrected for the partial volume of cerebrospinal fluid. Results: In the left dorsolateral prefrontal cortex, the N-acetyl aspartate/creatine ratio of patients was significantly higher than that of controls, and this was due to the decrease of creatine concentration instead of the increase of N-acetyl aspartate concentration. Furthermo