rab4b is a small gtpase involved in the control of the glucose transporter glut4 localization in adipocyterab4b的控制是一个小gtpase参与葡萄糖转运蛋白在脂肪细胞glut4本地化.pdfVIP

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rab4b is a small gtpase involved in the control of the glucose transporter glut4 localization in adipocyterab4b的控制是一个小gtpase参与葡萄糖转运蛋白在脂肪细胞glut4本地化.pdf

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rab4b is a small gtpase involved in the control of the glucose transporter glut4 localization in adipocyterab4b的控制是一个小gtpase参与葡萄糖转运蛋白在脂肪细胞glut4本地化

Rab4b Is a Small GTPase Involved in the Control of the Glucose Transporter GLUT4 Localization in Adipocyte 1,2 1,2 ´ ´ 1,2 ´ 1,2 ´ Vincent Kaddai , Teresa Gonzalez , Frederique Keslair , Thierry Gremeaux , Stephanie Bonnafous2,3,4, Jean Gugenheim2,3,4, Albert Tran2,3,4, Philippe Gual2,3,4, Yannick Le Marchand- Brustel1,2,3,4, Mireille Cormont1,2* ´ ´ ´ ´ 1 INSERM U895, Centre Mediterraneen de Medecine Moleculaire (C3M), Team 7, Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France, 2 Faculty of ´ ´ ´ ´ Medicine, University of Nice/Sophia-Antipolis, Nice, France, 3 INSERM U895, Centre Mediterraneen de Medecine Moleculaire (C3M), Team 8, Hepatic Complications in ˆ ˆ Obesity, Faculty of Medicine, University of Nice/Sophia-Antipolis, Nice, France, 4 CHU of Nice, Pole Digestif, Hopital Archet 2, Nice, France Abstract Background: Endosomal small GTPases of the Rab family, among them Rab4a, play an essential role in the control of the glucose transporter GLUT4 trafficking, which is essential for insulin-mediated glucose uptake. We found that adipocytes also expressed Rab4b and we observed a consistent decrease in the expression of Rab4b mRNA in human and mice adipose tissue in obese diabetic states. These results led us to study this poorly characterized Rab member and its potential role in glucose transport. Methodology/Principal Findings: We used 3T3-L1 adipocytes to study by imaging approaches the localization of Rab4b and