recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates重组水泡性口炎病毒疫苗向量表达filovirus糖蛋白在非人灵长类动物缺乏神经毒性.pdfVIP

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2017-09-09 发布于上海
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recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates重组水泡性口炎病毒疫苗向量表达filovirus糖蛋白在非人灵长类动物缺乏神经毒性.pdf

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recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates重组水泡性口炎病毒疫苗向量表达filovirus糖蛋白在非人灵长类动物缺乏神经毒性

Recombinant Vesicular Stomatitis Virus Vaccine Vectors Expressing Filovirus Glycoproteins Lack Neurovirulence in Nonhuman Primates Chad E. Mire1,2, Andrew D. Miller3,4, Angela Carville3,5, Susan V. Westmoreland3,4, Joan B. Geisbert1,2, 3,6 7 8 1,2 Keith G. Mansfield , Heinz Feldmann , Lisa E. Hensley *, Thomas W. Geisbert 1 Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas, United States of America, 2 Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America, 3 Harvard Medical School, Boston, Massachusetts, United States of America, 4 Division of Comparative Pathology, New England Primate Research Center, Southborough, Massachusetts, United States of America, 5 Department of Pathology, New England Primate Research Center, Southborough, Massachusetts, United States of America, 6 Division of Primate Resources, New England Primate Research Center, Southborough, Massachusetts, United States of America, 7 Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America, 8 Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America Abstract The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic fever with high mortality in humans and nonhuman primates. Among the most promising filovirus vaccines under development is a system based on recombinant vesicular stomatitis virus (rVSV) that expresses an individual filovirus glycoprotein (GP) in place of the VSV glycoprotein (G). The main concern with all replication-competent vac