原创力文档recombination and population mosaic of a multifunctional viral gene, adeno-associated virus cap多功能病毒基因重组和人口马赛克,腺相关病毒的帽子.pdfVIP
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recombination and population mosaic of a multifunctional viral gene, adeno-associated virus cap多功能病毒基因重组和人口马赛克,腺相关病毒的帽子
Recombination and Population Mosaic of a
Multifunctional Viral Gene, Adeno-Associated Virus cap
1 1,2 1,3
Yasuhiro Takeuchi *, Richard Myers , Olivier Danos
1 Medical Reserach Council (MRC)/UCL Centre for Medical Molecular Virology, Division of Infection and Immunology, University College London, London, United Kingdom,
´ ´ ´ ´
2 Centre for Infections, Health Protection Agency, London, United Kingdom, 3 Institut National de la Sante et de la Recherche Medicale (INSERM), U781, Institut Federatif
ˆ
de Recherche Necker Enfants Malades (IFR 94), Hopital Necker Enfants Malades, Paris, France
Abstract
Homologous recombination is a dominant force in evolution and results in genetic mosaics. To detect evidence of
recombination events and assess the biological significance of genetic mosaics, genome sequences for various viral
populations of reasonably large size are now available in the GenBank. We studied a multi-functional viral gene, the adeno-
associated virus (AAV) cap gene, which codes for three capsid proteins, VP1, VP2 and VP3. VP1-3 share a common C-terminal
domain corresponding to VP3, which forms the viral core structure, while the VP1 unique N-terminal part contains an
enzymatic domain with phospholipase A2 activity. Our recombinant detection program (RecI) revealed five novel
recombination events, four of which have their cross-over points in the N-terminal, VP1 and VP2 unique region. Comparison
of phylogenetic trees for different ca
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