recombination form and epidemiology of hiv-1 unique recombinant strains identified in yunnan, china复合形式和流行病学hiv - 1独特的重组菌株在云南,中国.pdfVIP

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recombination form and epidemiology of hiv-1 unique recombinant strains identified in yunnan, china复合形式和流行病学hiv - 1独特的重组菌株在云南,中国.pdf

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recombination form and epidemiology of hiv-1 unique recombinant strains identified in yunnan, china复合形式和流行病学hiv - 1独特的重组菌株在云南,中国

Recombination Form and Epidemiology of HIV-1 Unique Recombinant Strains Identified in Yunnan, China 1 1,3 2 1 2 1 1 2 Lin Li , Lili Chen , Shaomin Yang , Tianyi Li , Jianjian Li , Yongjian Liu , Lei Jia , Bihui Yang , 1 1 1 1 1 1 Zuoyi Bao , Hanping Li , Xiaolin Wang , Daomin Zhuang , Siyang Liu , Jingyun Li * 1 Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China, 2 Yunnan Provincial Hospital Infectious Disease, AIDS Care Center (YNACC), Kunming, Yunnan, China, 3 Urumqi General Hospital of Lanzhou Military Area Command, Urumqi, Xinjiang, China Abstract Several studies identified HIV-1 recombination in some distinct areas in Yunnan, China. However, no comprehensive studies had been fulfilled in the whole province up to now. To illustrate the epidemiology and recombination form of Unique Recombinant Forms (URFs) circulating in Yunnan, 788 HIV-1 positive individuals residing in 15 prefectures of Yunnan were randomly enrolled into the study. Full-length gag and pol genes were amplified and sequenced. Maximum likelihood tree was constructed for phylogenetic analysis. Recombinant breakpoints and genomic schematics were identified with online software jpHMM. 63 (10.2%) unique recombinant strains were identified from 617 strains with subtypes. The URFs distributed significantly differently among prefectures (Pearson chi-square test, P,0.05). IDUs contained more URFs than sexual transmitted population (Pearson chi-square test, P,0.05). Two main recombinant forms were