原创力文档rack-1 acts with rac gtpase signaling and unc-115ablim in caenorhabditis elegans axon pathfinding and cell migrationrack-1行为与rac gtpase信号和unc - 115 ablim线虫轴突寻路和细胞迁移.pdfVIP
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rack-1 acts with rac gtpase signaling and unc-115ablim in caenorhabditis elegans axon pathfinding and cell migrationrack-1行为与rac gtpase信号和unc - 115 ablim线虫轴突寻路和细胞迁移
RACK-1 Acts with Rac GTPase Signaling and UNC-115/
abLIM in Caenorhabditis elegans Axon Pathfinding and
Cell Migration
Rafael S. Demarco, Erik A. Lundquist*
Programs in Genetics and Molecular, Cellular, and Developmental Biology, Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of
America
Abstract
Migrating cells and growth cones extend lamellipodial and filopodial protrusions that are required for outgrowth and
guidance. The mechanisms of cytoskeletal regulation that underlie cell and growth cone migration are of much interest to
developmental biologists. Previous studies have shown that the Arp2/3 complex and UNC-115/abLIM act redundantly to
mediate growth cone lamellipodia and filopodia formation and axon pathfinding. While much is known about the
regulation of Arp2/3, less is known about regulators of UNC-115/abLIM. Here we show that the Caenorhabditis elegans
counterpart of the Receptor for Activated C Kinase (RACK-1) interacts physically with the actin-binding protein UNC-115/
abLIM and that RACK-1 is required for axon pathfinding. Genetic interactions indicate that RACK-1 acts cell-autonomously in
the UNC-115/abLIM pathway in axon pathfinding and lamellipodia and filopodia formation, downstream of the CED-10/Rac
GTPase and in parallel to MIG-2/RhoG. Furthermore, we show that RACK-1 is involved in migration of the gonadal distal tip
cells and that the signaling pathways involved in this process might be distinct from those involved in axon pathfinding. In
sum, these studies pinpoint RACK-1 as a component of a novel signaling pathway involving Rac GTPases and UNC-115/
abLIM and suggest that RACK-1 might be involved in the regulation of the actin cytoskeleton and lamellipodia and filopodia
formation in migrating cells and growth cones.
Citation: Demarco RS
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