reconstitution of mammary epithelial morphogenesis by murine embryonic stem cells undergoing hematopoietic stem cell differentiation乳腺上皮细胞形态发生的重组小鼠胚胎干细胞进行造血干细胞分化.pdfVIP

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reconstitution of mammary epithelial morphogenesis by murine embryonic stem cells undergoing hematopoietic stem cell differentiation乳腺上皮细胞形态发生的重组小鼠胚胎干细胞进行造血干细胞分化.pdf

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reconstitution of mammary epithelial morphogenesis by murine embryonic stem cells undergoing hematopoietic stem cell differentiation乳腺上皮细胞形态发生的重组小鼠胚胎干细胞进行造血干细胞分化

Reconstitution of Mammary Epithelial Morphogenesis by Murine Embryonic Stem Cells Undergoing Hematopoietic Stem Cell Differentiation 1 3 1 1 2,4. Shuxian Jiang , Byeong-Chel Lee , Yigong Fu , Shalom Avraham , Bing Lim , Hava Karsenty 1 . Avraham * 1 Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, 2 Hematology and Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, 3 University of Pittsburgh School of Medicine, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America, 4 Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore Abstract Background: Mammary stem cells are maintained within specific microenvironments and recruited throughout lifetime to reconstitute de novo the mammary gland. Mammary stem cells have been isolated through the identification of specific cell surface markers and in vivo transplantation into cleared mammary fat pads. Accumulating evidence showed that during the reformation of mammary stem cell niches by dispersed epithelial cells in the context of the intact epithelium-free mammary stroma, non-mammary epithelial cells may be sequestered and reprogrammed to perform mammary epithelial cell functions and to adopt mammary epithelial characteristics during reconstruction of mammary epithelium in regenerating mammary tissue in vivo. Methodology/Principal Findings: To examine whether other types of progenitor cells are able to contribute to mammary branching morphogenesis, we examined the potential of murine embryonic stem (mES) cells, undergoing h