random phenotypic variation of yeast (saccharomyces cerevisiae) single-gene knockouts fits a double pareto-lognormal distribution随机的表型变异的酵母(酿酒酵母)单基因淘汰赛中适合双pareto-lognormal分布.pdfVIP

Random Phenotypic Variation of Yeast (Saccharomyces cerevisiae) Single-Gene Knockouts Fits a Double Pareto- Lognormal Distribution 1 2,3 1,4 John H. Graham *, Daniel T. Robb , Amy R. Poe 1 Department of Biology, Berry College, Mount Berry, Georgia, United States of America, 2 Department of Physics, Astronomy, and Geology, Berry College, Mount Berry, Georgia, United States of America, 3 Department of Mathematics, Computer Science and Physics, Roanoke College, Salem, Virginia, United States of America, 4 Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, Georgia, United States of America Abstract Background: Distributed robustness is thought to influence the buffering of random phenotypic variation through the scale-free topology of gene regulatory, metabolic, and protein-protein interaction networks. If this hypothesis is true, then the phenotypic response to the perturbation of particular nodes in such a network should be proportional to the number of links those nodes make with neighboring nodes. This suggests a probability distribution approximating an inverse power- law of random phenotypic variation. Zero phenotypic variation, however, is impossible, because random molecular and cellular processes are essential to normal development. Consequently, a more realistic distribution should have a y-intercept close to zero in the lower tail, a mode greater than zero, and a long (fat) upper tail. The double Pareto-lognormal (DPLN) distribution is an ideal candidate distribution. It consists of a mixture of a lognormal body and upper and lower power-law tails. Objective and Methods: If our assumptions are true, the DPLN distribution should provide a better fit to random phenotypic variation in a large series