reduced hippocampal volume in healthy young apoe4 carriers an mri study减少海马体积在健康年轻apoe4运营商mri研究.pdfVIP

Reduced Hippocampal Volume in Healthy Young ApoE4 Carriers: An MRI Study 1 2 1 3 1 1 Laurence O’Dwyer *, Franck Lamberton , Silke Matura , Colby Tanner , Monika Scheibe , Julia Miller , 4 1 1 Dan Rujescu , David Prvulovic , Harald Hampel 1 Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany, 2 UMS 3408, CNRS, University of Caen, GIP CYCERON, Caen, France, 3 Department of Zoology, Trinity College Dublin, Dublin, Ireland, 4 Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany Abstract The E4 allele of the ApoE gene has consistently been shown to be related to an increased risk of Alzheimer’s disease (AD). The E4 allele is also associated with functional and structural grey matter (GM) changes in healthy young, middle-aged and older subjects. Here, we assess volumes of deep grey matter structures of 22 healthy younger ApoE4 carriers and 22 non- carriers (20–38 years). Volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, pallidum, putamen, thalamus and brain stem were calculated by FMRIB’s Integrated Registration and Segmentation Tool (FIRST) algorithm. A significant drop in volume was found in the right hippocampus of ApoE4 carriers (ApoE4+) relative to non-carriers (ApoE42), while there was a borderline significant decrease in the volume of the left hippocampus of ApoE4 carriers. The volumes of no other structures were found to be significantly affected by genotype. Atrophy has been found to be a sensitive marker of neurodegenerative changes, and our results show that within a healthy young population, the presence o